Chylomicrons are elevated in which lipid disorder due to lipase deficiency?

Chylomicrons are elevated in which lipid disorder due to lipase deficiency?

• A. LDL receptor deficiency
• B. Chylomicrons
• C. Chylomicrons are not elevated
• D. VLDL deficiency

Answer: (C)

When lipoprotein lipase (LPL) is defective, triglyceride-rich chylomicrons cannot be hydrolyzed and cleared from circulation. This causes a buildup of chylomicrons in the blood, leading to marked chylomicronemia and very high triglycerides. The disorder described by this lipase deficiency is familial hyperchylomicronemia (type I). So the correct concept is that chylomicrons are elevated. LDL receptor deficiency affects LDL clearance, not chylomicrons; VLDL deficiency changes VLDL-related triglycerides but does not primarily cause chylomicron elevation.

When lipoprotein lipase (LPL) is defective, triglyceride-rich chylomicrons cannot be hydrolyzed and cleared from circulation. This causes a buildup of chylomicrons in the blood, leading to marked chylomicronemia and very high triglycerides. The disorder described by this lipase deficiency is familial hyperchylomicronemia (type I). So the correct concept is that chylomicrons are elevated. LDL receptor deficiency affects LDL clearance, not chylomicrons; VLDL deficiency changes VLDL-related triglycerides but does not primarily cause chylomicron elevation.